IFIB – Interfakultäres Institut für Biochemie


2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 - 1989


Müller, A., Dickmanns, A., Resch, C., Schäkel, K., Hailfinger, S., Dobbelstein, M., Schulze-Osthoff, K., & Kramer, D. The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. J Clin Invest. (2020). In press

Bucher, P., Erdmann, T., Grondona, P., Xu, W., Schmitt, A., Schürch, C., Zapukhlyak, M., Schönfeld, C., Serfling, E., Kramer, D., Grau, M., Klener, P., Lengerke, C., Schulze-Osthoff, K., Lenz, G., & Hailfinger, S. Targeting chronic NFAT activation with calcineurin inhibitors in diffuse large B-cell lymphoma. Blood, 135(2), 121–132. (2020)

Grondona, P., Bucher, P., Schmitt, A., Schönfeld, C., Streibl, B., Müller, A., Essmann, F., Liberatori, S., Mohammed, S., Hennig, A., Kramer, D., Schulze-Osthoff, K., Hailfinger, S. Threonine Phosphorylation of IκBζ Mediates Inhibition of Selective Proinflammatory Target Genes. J Invest Dermatol. (2020)


Dannenmann, B., Zahabi, A., Mir, P., Oswald, B., Bernhard, R., Klimiankou, M., Morishima, T., Schulze-Osthoff, K., Zeidler, C., Kanz, L., Lachmann, N., Moritz, T., Welte, K., Skokowa, J. Human iPSC-based model of severe congenital neutropenia reveals elevated UPR and DNA damage in CD34(+) cells preceding leukemic transformation. Exp Hematol 71, 51-60. (2019)

Lorscheid, S., Müller, A., Löffler, J., Resch, C., Bucher, P., Kurschus, F.C., Waisman, A., Schäkel, K., Hailfinger, S., Schulze-Osthoff, K., Kramer, D. Keratinocyte-derived IκBζ drives psoriasis and associated systemic inflammation. JCI Insight 4. (2019)

Nasri, M., Mir, P., Dannenmann, B., Amend, D., Skroblyn, T., Xu, Y., Schulze-Osthoff, K., Klimiankou, M., Welte, K., and Skokowa, J. Fluorescent labeling of CRISPR/Cas9 RNP for gene knockout in HSPCs and iPSCs reveals an essential role for GADD45b in stress response. Blood Adv 3, 63-71. (2019)


Grondona, P., Bucher, P., Schulze-Osthoff, K., Hailfinger, S., and Schmitt, A. NF-κB Activation in Lymphoid Malignancies: Genetics, Signaling, and Targeted Therapy. Biomedicines 6. (2018)

Müller, A., Hennig, A., Lorscheid, S., Grondona, P., Schulze-Osthoff, K., Hailfinger, S., and Kramer, D.  IκBζ is a key transcriptional regulator of IL-36-driven psoriasis-related gene expression in keratinocytes. Proc Natl Acad Sci U S A 115, 10088-10093. (2018)

Nocker, A., Shah, M., Dannenmann, B., Schulze-Osthoff, K., Wingender, J., and Probst, A.J. Assessment of UV-C-induced water disinfection by differential PCR-based quantification of bacterial DNA damage. J Microbiol Methods 149, 89-95. (2018)

Schmitt, A., Schulze-Osthoff, K., and Hailfinger, S. Correspondence: T cells are compromised in tetracycline transactivator transgenic mice. Cell Death Differ 25, 634-636 (2018)

Stehle, D., Grimm, M., Einsele-Scholz, S., Ladwig, F., Johänning, J., Fischer, G., Gillissen, B., Schulze-Osthoff, K., and Essmann, F.. Contribution of BH3-domain and Transmembrane-domain to the Activity and Interaction of the Pore-forming Bcl-2 Proteins Bok, Bak, and Bax. Sci Rep 8, 12434. (2018)

Wandrer, F., Han, B., Liebig, S., Schlue, J., Manns, M.P., Schulze-Osthoff, K., and Bantel, H.. Senescence mirrors the extent of liver fibrosis in chronic hepatitis C virus infection. Aliment Pharmacol Ther 48, 270-280. (2018)


Bantel, H., Wandrer, F., Bock, B., Kirstein, M.M., and Schulze-Osthoff, K.. Letter: cytokeratin-18 as a biomarker of hepatocellular carcinoma regression after transarterial chemoembolization. Authors' reply. Aliment Pharmacol Ther 45, 184-185. (2017)

Dannenmann, B., Lehle, S., Lorscheid, S., Huber, S.M., Essmann, F., and Schulze-Osthoff, K.. Simultaneous quantification of DNA damage and mitochondrial copy number by long-run DNA-damage quantification (LORD-Q). Oncotarget 8, 112417-112425. (2017)

John, K., Hardtke-Wolenski, M., Jaeckel, E., Manns, M.P., Schulze-Osthoff, K., and Bantel, H.. Increased apoptosis of regulatory T cells in patients with active autoimmune hepatitis. Cell Death Dis 8, 3219. (2017)

Schulze-Osthoff, K., and Bantel, H.. Macrophage p38 kinase inhibition for liver regeneration. Febs j 284, 4196-4199. (2017)

Van Nuffel, E., Schmitt, A., Afonina, I.S., Schulze-Osthoff, K., Beyaert, R., and Hailfinger, S.. CARD14-Mediated Activation of Paracaspase MALT1 in Keratinocytes: Implications for Psoriasis. J Invest Dermatol 137, 569-575. (2017)


Dannenmann, B., Lehle, S., Essmann, F., and Schulze-Osthoff, K. Genome surveillance in pluripotent stem cells: Low apoptosis threshold and efficient antioxidant defense. Mol Cell Oncol 3, e1052183. (2016).

Einsele-Scholz, S., Malmsheimer, S., Bertram, K., Stehle, D., Johänning, J., Manz, M., Daniel, P.T., Gillissen, B.F., Schulze-Osthoff, K., and Essmann, F.. Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak. J Cell Sci 129, 2213-2223. (2016a)

Hailfinger, S., Schmitt, A., and Schulze-Osthoff, K.. The paracaspase MALT1 dampens NF-κB signalling by cleaving the LUBAC subunit HOIL-1. Febs j 283, 400-402. (2016)

Hörber, S., Hildebrand, D.G., Lieb, W.S., Lorscheid, S., Hailfinger, S., Schulze-Osthoff, K., Essmann, F.. The Atypical Inhibitor of NF-κB, IκBζ, Controls Macrophage Interleukin-10 Expression. J Biol Chem 291, 12851-12861. (2016)

Schmitt, A., Grondona, P., Maier, T., Brändle, M., Schönfeld, C., Jäger, G., Kosnopfel, C., Eberle, F.C., Schittek, B., Schulze-Osthoff, K., Yazdi, A.S., Hailfinger S.. MALT1 Protease Activity Controls the Expression of Inflammatory Genes in Keratinocytes upon Zymosan Stimulation. J Invest Dermatol 136, 788-797. (2016)

Tammam, S., Malak, P., Correa, D., Rothfuss, O., Azzazy, H.M., Lamprecht, A., and Schulze-Osthoff, K.. Nuclear delivery of recombinant OCT4 by chitosan nanoparticles for transgene-free generation of protein-induced pluripotent stem cells. Oncotarget 7, 37728-37739. (2016)


Dannenmann, B., Lehle, S., Hildebrand, D.G., Kübler, A., Grondona, P., Schmid, V., Holzer, K., Fröschl, M., Essmann, F., Rothfuss, O., Schulze-Osthoff K. High glutathione and glutathione peroxidase-2 levels mediate cell-type-specific DNA damage protection in human induced pluripotent stem cells. Stem Cell Reports 4, 886-898. (2015)

Johansen, C., Mose, M., Ommen, P., Bertelsen, T., Vinter, H., Hailfinger, S., Lorscheid, S., Schulze-Osthoff, K., and Iversen, L.. IκBζ is a key driver in the development of psoriasis. Proc Natl Acad Sci U S A 112, E5825-5833. (2015)

Malak, P.N., Dannenmann, B., Hirth, A., Rothfuss, O.C., and Schulze-Osthoff, K.. Novel AKT phosphorylation sites identified in the pluripotency factors OCT4, SOX2 and KLF4. Cell Cycle 14, 3748-3754. (2015)


Lehle S, Hildebrand DG, Merz B, Malak PN, Becker MS, Schmezer P, Essmann F, Schulze-Osthoff K, Rothfuss O. LORD-Q: a long-run real-time PCR-based DNA-damage quantification method for nuclear and mitochondrial genome analysis. Nucleic Acids Res, in press (2014).

Seidl MD, Nunes F, Fels B, Hildebrandt I, Schmitz W, Schulze-Osthoff K, Müller FU. A novel intronic promoter of the Crem gene induces small ICER (smICER) isoforms. FASEB J 28, 143-52 (2014).

Weiland T, Lampe J, Essmann F, Venturelli S, Berger A, Bossow S, Berchtold S, Schulze-Osthoff K, Lauer UM, Bitzer M. Enhanced killing of therapy-induced senescent tumor cells by oncolytic measles vaccine viruses. Int J Cancer 134, 235-43 (2014).

Bantel H, John K, Schulze-Osthoff K. Robust Detection of Liver Steatosis and Staging of NAFLD by an Improved ELISA for Serum Cytokeratin-18 Fragments. Am J Gastroenterol 109, 140-1 (2014).


Garbers C, Kuck F, Aparicio-Siegmund S, Konzak K, Kessenbrock M, Sommerfeld A, Häussinger D, Lang PA, Brenner D, Mak TW, Rose-John S, Essmann F, Schulze-Osthoff K, Piekorz RP, Scheller J. Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR). Cell Cycle 12, 3421-32 (2013).

ohn K, Wielgosz S, Schulze-Osthoff K, Bantel H, Hass R. Increased plasma levels of CK-18 as potential cell death biomarker in patients with HELLP syndrome. Cell Death Dis 4:e886 (2013).

Venturelli S, Berger A, Weiland T, Essmann F, Waibel M, Nuebling T, Häcker S, Schenk M, Schulze-Osthoff K, Salih HR, Fulda S, Sipos B, Johnstone RW, Lauer UM, Bitzer M. Differential induction of apoptosis and senescence by the DNA methyltransferase inhibitors 5-azacytidine and 5-aza-2'-deoxycytidine in solid tumor cells. Mol Cancer Ther 12, 2226-36 (2013).

Bareiss PM, Paczulla A, Wang H, Schairer R, Wiehr S, Kohlhofer U, Rothfuss OC, Fischer A, Perner S, Staebler A, Wallwiener D, Fend F, Fehm T, Pichler B, Kanz L, Quintanilla-Martinez L, Schulze-Osthoff K, Essmann F, Lengerke C. SOX2 expression associates with stem cell state in human ovarian carcinoma. Cancer Res 73, 5544-55 (2013).

Alexander E, Hildebrand DG, Kriebs A, Obermayer K, Manz M, Rothfuss O, Schulze-Osthoff K, Essmann F. IκBζ is a regulator of the senescence-associated secretory phenotype in DNA damage- and oncogene-induced senescence. J Cell Sci 126, 3738-45 (2013).

Wilhelmi V, Fischer U, Weighardt H, Schulze-Osthoff K, Nickel C, Stahlmecke B, Kuhlbusch TA, Scherbart AM, Esser C, Schins RP, Albrecht C. Zinc oxide nanoparticles induce necrosis and apoptosis in macrophages in a p47phox- and Nrf2-independent manner. PLoS One 8, e65704 (2013).

Hildebrand DG, Lehle S, Borst A, Haferkamp S, Essmann F, Schulze-Osthoff K. α-Fucosidase as a novel convenient biomarker for cellular senescence. Cell Cycle 12, 1922-7 (2013).

Hildebrand DG, Alexander E, Hörber S, Lehle S, Obermayer K, Münck NA, Rothfuss O, Frick JS, Morimatsu M, Schmitz I, Roth J, Ehrchen JM, Essmann F, Schulze-Osthoff K. IκBζ is a transcriptional key regulator of CCL2/MCP-1. J Immunol 190, 4812-20 (2013).

Braumüller H, Wieder T, Brenner E, Aßmann S, Hahn M, Alkhaled M, Schilbach K, Essmann F, Kneilling M, Griessinger C, Ranta F, Ullrich S, Mocikat R, Braungart K, Mehra T, Fehrenbacher B, Berdel J, Niessner H, Meier F, van den Broek M, Häring HU, Handgretinger R, Quintanilla-Martinez L, Fend F, Pesic M, Bauer J, Zender L, Schaller M, Schulze-Osthoff K, Röcken M. T-helper-1-cell cytokines drive cancer into senescence. Nature 494, 361-5 (2013).

Keil E, Höcker R, Schuster M, Essmann F, Ueffing N, Hoffman B, Liebermann DA, Pfeffer K, Schulze-Osthoff K, Schmitz I. Phosphorylation of Atg5 by the Gadd45β-MEKK4-p38 pathway inhibits autophagy. Cell Death Differ 20, 321-32 (2013).

Wahl K, Siegemund M, Lehner F, Vondran F, Nüssler A, Länger F, Krech T, Kontermann R, Manns MP, Schulze-Osthoff K, Pfizenmaier K, Bantel H. Increased apoptosis induction in hepatocellular carcinoma by a novel tumor-targeted TRAIL fusion protein combined with bortezomib. Hepatology 57, 625-36 (2013).

Bantel H, Schulze-Osthoff K. TNF antagonists in IBD: Novel antiinflammatory mechanisms beyond cytokine inhibition. Inflamm Bowel Dis 19, E51-2 (2013).

Konantz M, André MC, Ebinger M, Grauer M, Wang H, Grzywna S, Rothfuss OC, Lehle S, Kustikova OS, Salih HR, Handgretinger R, Fend F, Baum C, Kanz L, Quintanilla-Martinez L, Schulze-Osthoff K, Essmann F, Lengerke C. EVI-1 modulates leukemogenic potential and apoptosis sensitivity in human acute lymphoblastic leukemia. Leukemia 27, 56-65 (2013).


Schuster M, Glauben R, Plaza-Sirvent C, Schreiber L, Annemann M, Floess S, Kühl AA, Clayton LK, Sparwasser T, Schulze-Osthoff K, Pfeffer K, Huehn J, Siegmund B, Schmitz I. IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor. Immunity 37, 998-1008 (2012).

Wahl K, Rosenberg W, Vaske B, Manns MP, Schulze-Osthoff K, Bahr MJ, Bantel H. Biopsy-controlled liver fibrosis staging using the enhanced liver fibrosis (ELF) score compared to transient elastography. PLoS One 7, e51906 (2012).

Rosenwald M, Koppe U, Keppeler H, Sauer G, Hennel R, Ernst A, Blume KE, Peter C, Herrmann M, Belka C, Schulze-Osthoff K, Wesselborg S, Lauber K. Serum-derived plasminogen is activated by apoptotic cells and promotes their phagocytic clearance. J Immunol 189, 5722-8 (2012).

Peter C, Waibel M, Keppeler H, Lehmann R, Xu G, Halama A, Adamski J, Schulze-Osthoff K, Wesselborg S, Lauber K. Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1. Autoimmunity 45, 568-73 (2012).

Bantel H, Schulze-Osthoff K. Mechanisms of cell death in acute liver failure. Front Physiol 3:79 (2012).

Lafont E, Dupont R, Andrieu-Abadie N, Okazaki T, Schulze-Osthoff K, Levade T, Benoist H, Ségui B. Ordering of ceramide formation and caspase-9 activation in CD95L-induced Jurkat leukemia T cell apoptosis. Biochim Biophys Acta 1821, 684-93 (2012).

Wilhelmi V, Fischer U, van Berlo D, Schulze-Osthoff K, Schins RP, Albrecht C. Evaluation of apoptosis induced by nanoparticles and fine particles in RAW 264.7 macrophages: facts and artefacts. Toxicol In Vitro 26, 323-34 (2012).

Bantel H, Schulze-Osthoff K. Can cell death biomarkers predict the outcome of acute liver failure? Liver Int 32, 346 (2012).

Joka D, Wahl K, Moeller S, Schlue J, Vaske B, Bahr MJ, Manns MP, Schulze-Osthoff K, Bantel H. Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis. Hepatology 55, 455-64 (2012).

Ruiz-Magaña MJ, Rodríguez-Vargas JM, Morales JC, Saldivia MA, Schulze-Osthoff K, Ruiz-Ruiz C. The DNA methyltransferase inhibitors zebularine and decitabine induce mitochondria-mediated apoptosis and DNA damage in p53 mutant leukemic T cells. Int J Cancer 130, 1195-207 (2012).

Essmann F, Schulze-Osthoff K. Translational approaches targeting the p53 pathway for anti-cancer therapy. Br J Pharmacol165, 328-44 (2012).

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Ghoreschi K, Brück J, Kellerer C, Deng C, Peng H, Rothfuss O, Hussain RZ, Gocke AR, Respa A, Glocova I, Valtcheva N, Alexander E, Feil S, Feil R, Schulze-Osthoff K, Rupec RA, Lovett-Racke AE, Dringen R, Racke MK, Röcken M. Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells. J Exp Med 208, 2291-303 (2011).

Ranta F, Leveringhaus J, Theilig D, Schulz-Raffelt G, Hennige AM, Hildebrand DG, Handrick R, Jendrossek V, Bosch F, Schulze-Osthoff K, Häring HU, Ullrich S. Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1. PLoS One 6, e28828 (2011).

Cappuccini F, Eldh T, Bruder D, Gereke M, Jastrow H, Schulze-Osthoff K, Fischer U, Köhler D, Stuschke M, Jendrossek V. New insights into the molecular pathology of radiation-induced pneumopathy. Radiother Oncol 101, 86-92 (2011).

Niyazi M, Zehentmayr F, Niemöller OM, Eigenbrod S, Kretzschmar H, Schulze-Osthoff K, Tonn JC, Atkinson M, Mörtl S, Belka C. MiRNA expression patterns predict survival in glioblastoma. Radiat Oncol 6, 153 (2011).

Manns J, Daubrawa M, Driessen S, Paasch F, Hoffmann N, Löffler A, Lauber K, Dieterle A, Alers S, Iftner T, Schulze-Osthoff K, Stork B, Wesselborg S. Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1. FASEB J 25, 3250-61 (2011).

Veltkamp C, Anstaett M, Wahl K, Möller S, Gangl S, Bachmann O, Hardtke-Wolenski M, Länger F, Stremmel W, Manns MP, Schulze-Osthoff K, Bantel H. Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNF{alpha} treatment. Gut 60, 1345-53 (2011).

Schulze-Osthoff K, Bantel H. Necrosis versus apoptosis in acetaminophen-induced hepatotoxicity. Hepatology 53, 1070 (2011).

Graupner V, Alexander E, Overkamp T, Rothfuss O, De Laurenzi V, Gillissen BF, Daniel PT, Schulze-Osthoff K, Essmann F. Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level. Cell Death Differ 18, 1130-9 (2011).

Guderian G, Peter C, Wiesner J, Sickmann A, Schulze-Osthoff K, Fischer U, Grimmler M. RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity. J Biol Chem 286, 1976-86 (2011).

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Schmidt S, Essmann F, Cirtea IC, Kuck F, Thakur HC, Singh M, Kletke A, Jänicke RU, Wiek C, Hanenberg H, Ahmadian MR, Schulze-Osthoff K, Nürnberg B, Piekorz RP. The centrosome and mitotic spindle apparatus in cancer and senescence. Cell Cycle 9, 4469-73 (2010).

Singh KK, Erkelenz S, Rattay S, Dehof AK, Hildebrandt A, Schulze-Osthoff K, Schaal H, Schwerk C. Human SAP18 mediates assembly of a splicing regulatory multiprotein complex via its ubiquitin-like fold. RNA 16, 2442-54 (2010).

Schmidt S, Schneider L, Essmann F, Cirstea IC, Kuck F, Kletke A, Jänicke RU, Wiek C, Hanenberg H, Ahmadian MR, Schulze-Osthoff K, Nürnberg B, Piekorz RP. The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program. Oncogene 29, 6184-92 (2010).

Brandt D, Volkmann X, Anstätt M, Länger F, Manns MP, Schulze-Osthoff K, Bantel H. Serum biomarkers of cell death for monitoring therapy response of gastrointestinal carcinomas. Eur J Cancer 46, 1464-73 (2010).

Lafont E, Milhas D, Carpentier S, Garcia V, Jin ZX, Umehara H, Okazaki T, Schulze-Osthoff K, Levade T, Benoist H, Ségui B. Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death. Cell Death Differ 17, 642-54 (2010).

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Blume KE, Soeroes S, Waibel M, Keppeler H, Wesselborg S, Herrmann M, Schulze-Osthoff K, Lauber K. Cell surface externalization of annexin A1 as a failsafe mechanism preventing inflammatory responses during secondary necrosis. Immunol 183, 8138-47 (2009).

Janssen K, Horn S, Niemann MT, Daniel PT, Schulze-Osthoff K, Fischer U. Inhibition of the ER Ca2+ pump forces multidrug-resistant cells deficient in Bak and Bax into necrosis. J Cell Sci 122, 4481-91 (2009).

Dalla Rosa I, Goffart S, Wurm M, Wiek C, Essmann F, Sobek S, Schroeder P, Zhang H, Krutmann J, Hanenberg H, Schulze-Osthoff K, Mielke C, Pommier Y, Boege F, Christensen MO. Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA. Nucleic Acids Res 37, 6414-28 (2009).

Bantel H, Schulze-Osthoff K. Cell death in sepsis: a matter of how, when, and where. Crit Care 13, 173 (2009).

Bantel H, Bahr MJ, Schulze-Osthoff K. An apoptosis biomarker for prediction of nonalcoholic steatohepatitis. Hepatology 50, 991 (2009).

Los M, Schulze-Osthoff K. Catching chromatin relaxation in act by flow cytometry. Cell Cycle 8, 2140-1 (2009).

Lindenblatt C, Schulze-Osthoff K, Totzke G. IkappaBzeta expression is regulated by miR-124a. Cell Cycle 8, 2019-23 (2009).

Hofer S, Rosenhagen C, Nakamura H, Yodoi J, Bopp C, Zimmermann JB, Goebel M, Schemmer P, Hoffmann K, Schulze-Osthoff K, Breitkreutz R, Weigand MA. Thioredoxin in human and experimental sepsis. Crit Care Med 37, 2155-9 (2009).

Ueffing N, Singh KK, Christians A, Thorns C, Feller AC, Nagl F, Fend F, Heikaus S, Marx A, Zotz RB, Brade J, Schulz WA, Schulze-Osthoff K, Schmitz I, Schwerk C. A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein. Blood 114, 572-9 (2009).

Vogler M, Weber K, Dinsdale D, Schmitz I, Schulze-Osthoff K, Dyer MJ, Cohen GM. Different forms of cell death induced by putative BCL2 inhibitors. Cell Death Differ 16, 1030-9 (2009).

Los M, Panigrahi S, Rashedi I, Mandal S, Stetefeld J, Essmann F, Schulze-Osthoff K. Apoptin, a tumor-selective killer. Biochim Biophys Acta 1793, 1335-42 (2009).

Los M, Maddika S, Erb B, Schulze-Osthoff K. Switching Akt: from survival signaling to deadly response. Bioessays 31, 492-5 (2009).

Graupner V, Schulze-Osthoff K, Essmann F, Jänicke RU. Functional characterization of p53beta and p53gamma, two isoforms of the tumor suppressor p53. Cell Cycle 8, 1238-48 (2009).

Sohn D, Graupner V, Neise D, Essmann F, Schulze-Osthoff K, Jänicke RU. Pifithrin-alpha protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53. Cell Death Differ 16, 869-78 (2009).

Maddika S, Panigrahi S, Wiechec E, Wesselborg S, Fischer U, Schulze-Osthoff K, Los M. Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity. Mol Cell Biol 29, 1235-48 (2009).


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Rudy A, López-Antón N, Barth N, Pettit GR, Dirsch VM, Schulze-Osthoff K, Rehm M, Prehn JH, Vogler M, Fulda S, Vollmar AM. Role of Smac in cephalostatin-induced cell death. Cell Death Differ 15, 1930-40 (2008).

Klonisch T, Wiechec E, Hombach-Klonisch S, Ande SR, Wesselborg S, Schulze-Osthoff K, Los M. Cancer stem cell markers in common cancers - therapeutic implications. Trends Mol Med 14, 450-60 (2008).

Hombach-Klonisch S, Panigrahi S, Rashedi I, Seifert A, Alberti E, Pocar P, Kurpisz M, Schulze-Osthoff K, Mackiewicz A, Los M. Adult stem cells and their trans-differentiation potential--perspectives and therapeutic applications. J Mol Med 86, 1301-14 (2008).

Hombach-Klonisch S, Paranjothy T, Wiechec E, Pocar P, Mustafa T, Seifert A, Zahl C, Gerlach KL, Biermann K, Steger K, Hoang-Vu C, Schulze-Osthoff K, Los M. Cancer stem cells as targets for cancer therapy: selected cancers as examples. Arch Immunol Ther Exp (Warsz) 56, 165-80 (2008).

Ueffing N, Schuster M, Keil E, Schulze-Osthoff K, Schmitz I. Up-regulation of c-FLIP short by NFAT contributes to apoptosis resistance of short-term activated T cells. Blood 112, 690-8 (2008).

Stampfuss JJ, Censarek P, Fischer JW, Kaber G, Rauch BH, Freidel K, Fischer U, Schulze-Osthoff K, Grosser T, Grandoch M, Schrör K, Weber AA. Complete downmodulation of P-selectin glycoprotein ligand in monocytes undergoing apoptosis. Arterioscler Thromb Vasc Biol 28, 1375-8 (2008).

Hassan M, Alaoui A, Feyen O, Mirmohammadsadegh A, Essmann F, Tannapfel A, Gulbins E, Schulze-Osthoff K, Hengge UR. The BH3-only member Noxa causes apoptosis in melanoma cells by multiple pathways. Oncogene 27, 4557-68 (2008).

Volkmann X, Anstaett M, Hadem J, Stiefel P, Bahr MJ, Lehner F, Manns MP, Schulze-Osthoff K, Bantel H. Caspase activation is associated with spontaneous recovery from acute liver failure. Hepatology 47, 1624-33 (2008).

Jänicke RU, Sohn D, Schulze-Osthoff K. The dark side of a tumor suppressor: anti-apoptotic p53. Cell Death Differ 15, 959-76 (2008).

Ueffing N, Keil E, Freund C, Kühne R, Schulze-Osthoff K, Schmitz I. Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment. Cell Death Differ 15, 773-82 (2008).

Knobloch J, Schmitz I, Götz K, Schulze-Osthoff K, Rüther U. Thalidomide induces limb anomalies by PTEN stabilization, Akt suppression, and stimulation of caspase-dependent cell death. Mol Cell Biol 28, 529-38 (2008).

Peter C, Waibel M, Radu CG, Yang LV, Witte ON, Schulze-Osthoff K, Wesselborg S, Lauber K. Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A. J Biol Chem 283, 5296-305 (2008).

Ghavami S, Kerkhoff C, Chazin WJ, Kadkhoda K, Xiao W, Zuse A, Hashemi M, Eshraghi M, Schulze-Osthoff K, Klonisch T, Los M. S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2. Biochim Biophys Acta 1783, 297-311 (2008).

Maddika S, Wiechec E, Ande SR, Poon IK, Fischer U, Wesselborg S, Jans DA, Schulze-Osthoff K, Los M. Interaction with PI3-kinase contributes to the cytotoxic activity of apoptin. Oncogene 27, 3060-5 (2008).

Tretiakova I, Blaesius D, Maxia L, Wesselborg S, Schulze-Osthoff K, Cinatl J Jr, Michaelis M, Werz O. Myrtucommulone from Myrtus communis induces apoptosis in cancer cells via the mitochondrial pathway involving caspase-9. Apoptosis 13, 119-31 (2008).

Frelin C, Imbert V, Bottero V, Gonthier N, Samraj AK, Schulze-Osthoff K, Auberger P, Courtois G, Peyron JF. Inhibition of the NF-kappaB survival pathway via caspase-dependent cleavage of the IKK complex scaffold protein and NF-kappaB essential modulator NEMO. Cell Death Differ 15, 152-60 (2008).

Neise D, Graupner V, Gillissen BF, Daniel PT, Schulze-Osthoff K, Jänicke RU, Essmann F. Activation of the mitochondrial death pathway is commonly mediated by a preferential engagement of Bak. Oncogene 27, 1387-96 (2008).

Schneider L, Essmann F, Kletke A, Rio P, Hanenberg H, Schulze-Osthoff K, Nürnberg B, Piekorz RP. TACC3 depletion sensitizes to paclitaxel-induced cell death and overrides p21WAF-mediated cell cycle arrest. Oncogene 27, 116-25 (2008).

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Fischer U, Janssen K, Schulze-Osthoff K. Does caspase inhibition promote clonogenic tumor growth? Cell Cycle 15, 3048-53 (2007).

Fischer U, Janssen K, Schulze-Osthoff K. Cutting-edge apoptosis-based therapeutics: a panacea for cancer? BioDrugs 21, 273-97 (2007).

Schulze-Osthoff K, Häussinger D. Apoptosis in the liver: a matter of ion fluxes and oxidative stress: Third International Conference of the Collaborative Research Center 'Experimental Hepatology' (SFB-575), Düsseldorf, Germany, 13-14 October 2006. Liver Int 27, 1039-44 (2007).

Volkmann X, Fischer U, Bahr MJ, Ott M, Lehner F, Macfarlane M, Cohen GM, Manns MP, Schulze-Osthoff K, Bantel H. Increased hepatotoxicity of tumor necrosis factor-related apoptosis-inducing ligand in diseased human liver. Hepatology 46, 1498-508 (2007).

Schneider L, Essmann F, Kletke A, Rio P, Hanenberg H, Wetzel W, Schulze-Osthoff K, Nürnberg B, Piekorz RP. The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival. J Biol Chem 282, 29273-83 (2007).

Janssen K, Pohlmann S, Jänicke RU, Schulze-Osthoff K, Fischer U. Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment. Blood 110, 3662-72 (2007).

Werdehausen R, Braun S, Essmann F, Schulze-Osthoff K, Walczak H, Lipfert P, Stevens MF. Lidocaine induces apoptosis via the mitochondrial pathway independently of death receptor signaling. Anesthesiology 107, 136-43 (2007).

Troeger A, Schmitz I, Siepermann M, Glouchkova L, Gerdemann U, Janka-Schaub GE, Schulze-Osthoff K, Dilloo D. Up-regulation of c-FLIPS+R upon CD40 stimulation is associated with inhibition of CD95-induced apoptosis in primary precursor B-ALL. Blood 110, 384-7 (2007).

Jänicke RU, Sohn D, Essmann F, Schulze-Osthoff K. The multiple battles fought by anti-apoptotic p21. Cell Cycle 6, 407-13 (2007).

Vutova P, Wirth M, Hippe D, Gross U, Schulze-Osthoff K, Schmitz I, Lüder CG. Toxoplasma gondii inhibits Fas/CD95-triggered cell death by inducing aberrant processing and degradation of caspase 8. Cell Microbiol 9, 1556-70 (2007).

Waibel M, Kramer S, Lauber K, Lupescu A, Manns J, Schulze-Osthoff K, Lang F, Wesselborg S. Mitochondria are not required for death receptor-mediated cytosolic acidification during apoptosis. Apoptosis 12, 623-30 (2007).

Viemann D, Barczyk K, Vogl T, Fischer U, Sunderkötter C, Schulze-Osthoff K, Roth J. MRP8/MRP14 impairs endothelial integrity and induces a caspase-dependent and -independent cell death program. Blood 109, 2453-60 (2007).

Samraj AK, Sohn D, Schulze-Osthoff K, Schmitz I. Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization. Mol Biol Cell 18, 84-93 (2007).

Janssen K, Hofmann TG, Jans DA, Hay RT, Schulze-Osthoff K, Fischer U. Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies. Oncogene 26, 1557-66 (2007).

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Fischer, U., Stroh, C., and Schulze-Osthoff, K. (2006). Unique and overlapping substrate specificities of caspase-8 and caspase-10. Oncogene 25, 152-159.

Jänicke, R.U., Sohn, D., Totzke, G., and Schulze-Osthoff, K. (2006). Caspase-10 in mouse or not? Science 312, 1874.

Samraj, A.K., Stroh, C., Fischer, U., and Schulze-Osthoff, K. (2006). The tyrosine kinase Lck is a positive regulator of the mitochondrial apoptosis pathway by controlling Bak expression. Oncogene 25, 186-197.

Schmitz, I., Meyer, C., and Schulze-Osthoff, K. (2006). CD95 ligand mediates T-cell receptor-induced apoptosis of a CD4+ CD8+ double positive thymic lymphoma. Oncogene 25, 7587-7596.

Sohn, D., Totzke, G., Essmann, F., Schulze-Osthoff, K., Levkau, B., and Jänicke, R.U. (2006a). The proteasome is required for rapid initiation of death receptor-induced apoptosis. Mol Cell Biol 26, 1967-1978.

Sohn, D., Totzke, G., Schulze-Osthoff, K., and Jänicke, R.U. (2006b). Friend or foe? The proteasome in combined cancer therapy. Cell Cycle 5, 841-845.

Totzke, G., Essmann, F., Pohlmann, S., Lindenblatt, C., Jänicke, R.U., and Schulze-Osthoff, K. (2006). A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding. J Biol Chem 281, 12645-12654.


Bantel, H., Beikler, T., Flemmig, T.F., and Schulze-Osthoff, K. (2005). Caspase activation is involved in chronic periodontitis. FEBS Lett 579, 5559-5564.

Fischer, U., and Schulze-Osthoff, K. (2005a). Apoptosis-based therapies and drug targets. Cell Death Differ 12 Suppl 1, 942-961.

Fischer, U., and Schulze-Osthoff, K. (2005b). New approaches and therapeutics targeting apoptosis in disease. Pharmacol Rev 57, 187-215.

Schwerk, C., and Schulze-Osthoff, K. (2005a). Methyltransferase inhibition induces p53-dependent apoptosis and a novel form of cell death. Oncogene 24, 7002-7011.

Schwerk, C., and Schulze-Osthoff, K. (2005b). Regulation of apoptosis by alternative pre-mRNA splicing. Mol Cell 19, 1-13.

Bantel, H., Lügering, A., Heidemann, J., Volkmann, X., Poremba, C., Strassburg, C.P., Manns, M.P., and Schulze-Osthoff, K. (2004). Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury. Hepatology 40, 1078-1087.

Essmann, F., Engels, I.H., Totzke, G., Schulze-Osthoff, K., and Jänicke, R.U. (2004). Apoptosis resistance of MCF-7 breast carcinoma cells to ionizing radiation is independent of p53 and cell cycle control but caused by the lack of caspase-3 and a caffeine-inhibitable event. Cancer Res 64, 7065-7072.

Bantel, H., and Schulze-Osthoff, K. (2003). Apoptosis in hepatitis C virus infection. Cell Death Differ 10 Suppl 1, S48-58.

Fischer, U., Jänicke, R.U., and Schulze-Osthoff, K. (2003). Many cuts to ruin: a comprehensive update of caspase substrates. Cell Death Differ 10, 76-100.

Schwerk, C., and Schulze-Osthoff, K. (2003). Non-apoptotic functions of caspases in cellular proliferation and differentiation. Biochem Pharmacol 66, 1453-1458.

Stroh, C., Held, J., Samraj, A.K., and Schulze-Osthoff, K. (2003). Specific inhibition of transcription factor NF-kappaB through intracellular protein delivery of I kappaBalpha by the Herpes virus protein VP22. Oncogene 22, 5367-5373.

Bantel, H., Schmitz, M.L., Raible, A., Gregor, M., and Schulze-Osthoff, K. (2002). Critical role of NF-kappaB and stress-activated protein kinases in steroid unresponsiveness. Faseb j 16, 1832-1834.

Brehm, B.R., Wolf, S.C., Freudenberg, J., Friedmann, F., Heinle, H., and Schulze-Osthoff, K. (2002). Modulation of the beta-adrenergic receptor system of vascular smooth muscle cells in vitro and in vivo by chronically elevated endothelin-1 levels. Biochem Pharmacol 63, 1361-1369.

Cotter, T., De Laurenzi, V., Walczak, H., Melino, G., and Schulze-Osthoff, K. (2002). The European death flying circus. Cell Death Differ 9, 591-592.

Los, M., Mozoluk, M., Ferrari, D., Stepczynska, A., Stroh, C., Renz, A., Herceg, Z., Wang, Z.Q., and Schulze-Osthoff, K. (2002). Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling. Mol Biol Cell 13, 978-988.

Bantel, H., Lügering, A., Poremba, C., Lügering, N., Held, J., Domschke, W., and Schulze-Osthoff, K. (2001a). Caspase activation correlates with the degree of inflammatory liver injury in chronic hepatitis C virus infection. Hepatology 34, 758-767.

Bantel, H., Ruck, P., Gregor, M., and Schulze-Osthoff, K. (2001b). Detection of elevated caspase activation and early apoptosis in liver diseases. Eur J Cell Biol 80, 230-239.

Brehm, B.R., Bock, C., Wesselborg, S., Pfeiffer, S., Schüler, S., and Schulze-Osthoff, K. (2001a). Prevention of human smooth muscle cell proliferation without induction of apoptosis by the topoisomerase I inhibitor topotecan. Biochem Pharmacol 61, 119-127.

Brehm, B.R., Wolf, S.C., Bertsch, D., Klaussner, M., Wesselborg, S., Schüler, S., and Schulze-Osthoff, K. (2001b). Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cells. Cardiovasc Res 49, 430-439.

Burek, C., Roth, J., Koch, H.G., Harzer, K., Los, M., and Schulze-Osthoff, K. (2001). The role of ceramide in receptor- and stress-induced apoptosis studied in acidic ceramidase-deficient Farber disease cells. Oncogene 20, 6493-6502.

Daniel, P.T., Wieder, T., Sturm, I., and Schulze-Osthoff, K. (2001). The kiss of death: promises and failures of death receptors and ligands in cancer therapy. Leukemia 15, 1022-1032.

Held, J., and Schulze-Osthoff, K. (2001). Potential and caveats of TRAIL in cancer therapy. Drug Resist Updat 4, 243-252.

Los, M., Stroh, C., Jänicke, R.U., Engels, I.H., and Schulze-Osthoff, K. (2001). Caspases: more than just killers? Trends Immunol 22, 31-34.

Stepczynska, A., Lauber, K., Engels, I.H., Janssen, O., Kabelitz, D., Wesselborg, S., and Schulze-Osthoff, K. (2001). Staurosporine and conventional anticancer drugs induce overlapping, yet distinct pathways of apoptosis and caspase activation. Oncogene 20, 1193-1202.

Totzke, G., Brüning, T., Vetter, H., Schulze-Osthoff, K., and Ko, Y. (2001). P53 downregulation in myelodysplastic syndrome--a quantitative analysis by competitive RT-PCR. Leukemia 15, 1663-1664.

Bantel, H., Berg, C., Vieth, M., Stolte, M., Kruis, W., and Schulze-Osthoff, K. (2000a). Mesalazine inhibits activation of transcription factor NF-kappaB in inflamed mucosa of patients with ulcerative colitis. Am J Gastroenterol 95, 3452-3457.

Bantel, H., Domschke, W., and Schulze-Osthoff, K. (2000b). Molecular mechanisms of glucocorticoid resistance. Gastroenterology 119, 1178-1179.

Bantel, H., Ruck, P., and Schulze-Osthoff, K. (2000c). In situ monitoring of caspase activation in hepatobiliary diseases. Cell Death Differ 7, 504-505.

Belka, C., Rudner, J., Wesselborg, S., Stepczynska, A., Marini, P., Lepple-Wienhues, A., Faltin, H., Bamberg, M., Budach, W., and Schulze-Osthoff, K. (2000). Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis. Oncogene 19, 1181-1190.

Los, M., Neubüser, D., Coy, J.F., Mozoluk, M., Poustka, A., and Schulze-Osthoff, K. (2000). Functional characterization of DNase X, a novel endonuclease expressed in muscle cells. Biochemistry 39, 7365-7373.

Schulze-Osthoff, K., and Stroh, C. (2000). Induced proximity model attracts NF-kappaB researchers. Cell Death Differ 7, 1025-1026.

Ferrari, D., Los, M., Bauer, M.K., Vandenabeele, P., Wesselborg, S., and Schulze-Osthoff, K. (1999a). P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death. FEBS Lett 447, 71-75.

Ferrari, D., Stroh, C., and Schulze-Osthoff, K. (1999b). P2X7/P2Z purinoreceptor-mediated activation of transcription factor NFAT in microglial cells. J Biol Chem 274, 13205-13210.

Los, M., Wesselborg, S., and Schulze-Osthoff, K. (1999). The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice. Immunity 10, 629-639.

Riehemann, K., Behnke, B., and Schulze-Osthoff, K. (1999). Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NF-kappaB. FEBS Lett 442, 89-94.

Wesselborg, S., Engels, I.H., Rossmann, E., Los, M., and Schulze-Osthoff, K. (1999). Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction. Blood 93, 3053-3063.

Bantel, H., Brüning, T., and Schulze-Osthoff, K. (1998). Activation of caspases by death receptors. Eur Cytokine Netw 9, 681-684.

Bauer, M.K., Vogt, M., Los, M., Siegel, J., Wesselborg, S., and Schulze-Osthoff, K. (1998). Role of reactive oxygen intermediates in activation-induced CD95 (APO-1/Fas) ligand expression. J Biol Chem 273, 8048-8055.

Ferrari, D., Stepczynska, A., Los, M., Wesselborg, S., and Schulze-Osthoff, K. (1998). Differential regulation and ATP requirement for caspase-8 and caspase-3 activation during CD95- and anticancer drug-induced apoptosis. J Exp Med 188, 979-984.

Schulze-Osthoff, K., Ferrari, D., Los, M., Wesselborg, S., and Peter, M.E. (1998). Apoptosis signaling by death receptors. Eur J Biochem 254, 439-459.

Stroh, C., and Schulze-Osthoff, K. (1998). Death by a thousand cuts: an ever increasing list of caspase substrates. Cell Death Differ 5, 997-1000.

Vogt, M., Bauer, M.K., Ferrari, D., and Schulze-Osthoff, K. (1998). Oxidative stress and hypoxia/reoxygenation trigger CD95 (APO-1/Fas) ligand expression in microglial cells. FEBS Lett 429, 67-72.

Bauer, M.K., Wesselborg, S., and Schulze-Osthoff, K. (1997). The Caenorhabditis elegans death protein Ced-4 contains a motif with similarity to the mammalian 'death effector domain'. FEBS Lett 402, 256-258.

Ferrari, D., Wesselborg, S., Bauer, M.K., and Schulze-Osthoff, K. (1997). Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65. J Cell Biol 139, 1635-1643.

Lieb, K., Fiebich, B.L., Berger, M., Bauer, J., and Schulze-Osthoff, K. (1997). The neuropeptide substance P activates transcription factor NF-kappa B and kappa B-dependent gene expression in human astrocytoma cells. J Immunol 159, 4952-4958.

Schulze-Osthoff, K., Bauer, M.K., Vogt, M., and Wesselborg, S. (1997a). Oxidative stress and signal transduction. Int J Vitam Nutr Res 67, 336-342.

Schulze-Osthoff, K., Ferrari, D., Riehemann, K., and Wesselborg, S. (1997b). Regulation of NF-kappa B activation by MAP kinase cascades. Immunobiology 198, 35-49.

Wesselborg, S., Bauer, M.K., Vogt, M., Schmitz, M.L., and Schulze-Osthoff, K. (1997). Activation of transcription factor NF-kappaB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways. J Biol Chem 272, 12422-12429.

Grimm, S., Bauer, M.K., Baeuerle, P.A., and Schulze-Osthoff, K. (1996). Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis. J Cell Biol 134, 13-23.

Makropoulos, V., Brüning, T., and Schulze-Osthoff, K. (1996). Selenium-mediated inhibition of transcription factor NF-kappa B and HIV-1 LTR promoter activity. Arch Toxicol 70, 277-283.

Pahl, H.L., Krauss, B., Schulze-Osthoff, K., Decker, T., Traenckner, E.B., Vogt, M., Myers, C., Parks, T., Warring, P., Mühlbacher, A., et al. (1996). The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB. J Exp Med 183, 1829-1840.

Schenk, H., Vogt, M., Dröge, W., and Schulze-Osthoff, K. (1996). Thioredoxin as a potent costimulus of cytokine expression. J Immunol 156, 765-771.

Schulze-Osthoff, K., Bauer, M.K., Vogt, M., and Los, M. (1996). Role of ICE-related and other proteases in Fas-mediated apoptosis. Cell Death Differ 3, 177-184.

Goebeler, M., Roth, J., Bröcker, E.B., Sorg, C., and Schulze-Osthoff, K. (1995). Activation of nuclear factor-kappa B and gene expression in human endothelial cells by the common haptens nickel and cobalt. J Immunol 155, 2459-2467.

Los, M., Dröge, W., Stricker, K., Baeuerle, P.A., and Schulze-Osthoff, K. (1995a). Hydrogen peroxide as a potent activator of T lymphocyte functions. Eur J Immunol 25, 159-165.

Los, M., Schenk, H., Hexel, K., Baeuerle, P.A., Dröge, W., and Schulze-Osthoff, K. (1995b). IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase. Embo j 14, 3731-3740.

Los, M., Van de Craen, M., Penning, L.C., Schenk, H., Westendorp, M., Baeuerle, P.A., Dröge, W., Krammer, P.H., Fiers, W., and Schulze-Osthoff, K. (1995c). Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis. Nature 375, 81-83.

Schulze-Osthoff, K., Los, M., and Baeuerle, P.A. (1995). Redox signalling by transcription factors NF-kappa B and AP-1 in lymphocytes. Biochem Pharmacol 50, 735-741.

Los, M., Dröge, W., and Schulze-Osthoff, K. (1994). Inhibition of activation of transcription factor AP-1 by CD28 signalling in human T-cells. Biochem J 302 ( Pt 1), 119-123.

Schenk, H., Klein, M., Erdbrügger, W., Dröge, W., and Schulze-Osthoff, K. (1994). Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1. Proc Natl Acad Sci U S A 91, 1672-1676.

Schulze-Osthoff, K. (1994). The Fas/APO-1 receptor and its deadly ligand. Trends Cell Biol 4, 421-426.

Schulze-Osthoff, K., Krammer, P.H., and Dröge, W. (1994a). Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death. Embo j 13, 4587-4596.

Schulze-Osthoff, K., Walczak, H., Dröge, W., and Krammer, P.H. (1994b). Cell nucleus and DNA fragmentation are not required for apoptosis. J Cell Biol 127, 15-20.

Schulze-Osthoff, K., Beyaert, R., Vandevoorde, V., Haegeman, G., and Fiers, W. (1993). Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF. Embo j 12, 3095-3104.

Schulze-Osthoff, K., Bakker, A.C., Vanhaesebroeck, B., Beyaert, R., Jacob, W.A., and Fiers, W. (1992). Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation. J Biol Chem 267, 5317-5323.

Schulze-Osthoff, K., and Fiers, W. (1991). Oxygen radicals as second messengers. Trends Cell Biol 1, 150.

Schulze-Osthoff, K., Goerdt, S., and Sorg, C. (1990). Expression of basic fibroblast growth factor (bFGF) in Kaposi's sarcoma: an immunohistologic study. J Invest Dermatol 95, 238-240.

Schulze-Osthoff, K., Michels, E., Overwien, B., and Sorg, C. (1989). Electroelution of antigens immobilized on antibody-linked affinity matrices. Anal Biochem 177, 314-317.